Neocortical Inhibitory Terminals Innervate Dendritic Spines Targeted by Thalamocortical Afferents
نویسندگان
چکیده
منابع مشابه
Neocortical inhibitory terminals innervate dendritic spines targeted by thalamocortical afferents.
Fast inhibition in the cortex is gated primarily at GABAergic synapses formed by local interneurons onto postsynaptic targets. Although GABAergic inputs to the somata and axon initial segments of neocortical pyramidal neurons are associated with direct inhibition of action potential generation, the role of GABAergic inputs to distal dendritic segments, including spines, is less well characteriz...
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GABA-releasing cortical interneurons are crucial for the neural transformations underlying sensory perception, providing "feedforward" inhibition that constrains the temporal window for synaptic integration. To mediate feedforward inhibition, inhibitory interneurons need to fire in response to ascending thalamocortical inputs, and most previous studies concluded that ascending inputs activate m...
متن کاملDendritic Spines
Dendritic spines are important sites of excitatory synaptic transmission and changes in the strength of these synapses are likely to underlie important higher brain functions such as learning and memory. Spines form biochemical compartments for isolating reactions that occur at one synapse from those at other synapses thereby providing a possible way to ensure the specificity of connections bet...
متن کاملDendritic Spines
What are they? Dendritic spines are small protrusions that emerge from the dendrites of neurons (Figure 1). Most excitatory synapses in the brain are found on spine heads. Typically, a spine consists of a bulbous head, volume 0.001–1 μm3, at the end of a thin spine neck, diameter around 0.1 μm. A 100 μm length dendrite can contain several hundred spines. The human cerebral cortex is thought to ...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2007
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.3846-06.2007